The Transgenic and Targeted Mutagenesis Core Facility is a university-wide shared resource dedicated to generating genetically-modified animals for investigators within the research community at Northwestern University and its affiliate institutions. Transgenic and gene targeting technologies are used to generate animal models in which the complexities of gene function and regulation can be studied. The ability to either express or functionally inactivate, in genetically modified animals, defined genes in a developmentally- and tissue-specific manner has lead to significant insights into and the understanding of the role genes play under both normal and abnormal conditions in many different and diverse fields of scientific study.

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